WWOX Polyclonal Antibody, 100ul Supplements Two transcript variants resulting from

Two transcript variants resulting from alternative splicing of the 3' terminal exon

in a tail-to-tail orientation

Interacts with BNLF1

SENP1 encodes a cysteine protease that specifically targets members of the small ubiquitin-like modifier (SUMO) protein family

transducing the TGF-beta signal from the cell surface to the cytoplasm

WWOX Polyclonal Antibody, 100ul Supplements Two transcript variants resulting fromWWOX (WW domain containing oxidoreductase) encodes a member of the short chain dehydrogenases reductases (SDR) protein family. WWOX spans the FRA16D common chromosomal fragile site and appears to function as a tumor suppressor gene. Expression of the encoded protein is able to induce apoptosis, while defects in this gene are associated with multiple types of cancer. Disruption of WWOX is also associated with autosomal recessive spinocerebellar ataxia