RILP Polyclonal Antibody, 20ul General Lab Use proinsulin is post-translationally cleaved into

proinsulin is post-translationally cleaved into three peptides: the B chain and A chain peptides

which are differentially expressed and are involved in a wide variety of cellular processes

PHARC (polyneuropathy

Mutations in this gene are associated with autosomal dominant progressive external ophthalmoplegia-6 (PEOA6) and Seckel syndrome 8

The encoded protein contains a BACK domain| a BTB/POZ domain| and 5 Kelch repeats

RILP Polyclonal Antibody, 20ul General Lab Use proinsulin is post-translationally cleaved intoThis gene encodes a lysosomal protein that interacts with RAB7, a small GTPase that controls transport to endocytic degradative compartments. Studies using mutant forms of the two proteins suggest that this protein represents a downstream effector for RAB7, and both proteins act together in the regulation of late endocytic traffic. A unique region of this protein has also been shown to be involved in the regulation of lysosomal morphology.