Vav1(Phospho Tyr174) Polyclonal Antibody, 50ul Funnels Multiple alternatively spliced transcript variants

Multiple alternatively spliced transcript variants differring in the 5' UTR have been described| but the full-length nature of these variants has not been determined

this receptor binds insulin-like growth factor with a high affinity

Interacts with the phosphorylated carboxyterminal domain of POLR2A

and dephosphorylate a wide spectrum of phospho-proteins involved in hematopoietic cell signaling

The protein encoded by this gene is a member of the tripartite motif (TRIM) family

Vav1(Phospho Tyr174) Polyclonal Antibody, 50ul Funnels Multiple alternatively spliced transcript variantsThis gene is a member of the VAV gene family. The VAV proteins are guanine nucleotide exchange factors (GEFs) for Rho family GTPases that activate pathways leading to actin cytoskeletal rearrangements and transcriptional alterations. The encoded protein is important in hematopoiesis, playing a role in T cell and B cell development and activation. The encoded protein has been identified as the specific binding partner of Nef proteins from HIV 1.