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VHL Polyclonal Antibody, 20ul[BT-AP09520] Vortex Mixer GALR1 inhibits adenylyl cyclase via

SKU: 29869313664

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VHL Polyclonal Antibody, 20ul[BT-AP09520] Vortex Mixer GALR1 inhibits adenylyl cyclase viaVon Hippel Lindau syndrome (VHL) is a dominantly inherited familial cancer syndrome predisposing to a variety of malignant and benign tumors. A germline mutation of VHL is the basis of familial inheritance of VHL syndrome. The protein encoded by VHL is a component of the protein complex that includes elongin B, elongin C, and cullin 2, and possesses ubiquitin ligase E3 activity. This protein is involved in the ubiquitination and degradation of hypoxia

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Description

GALR1 inhibits adenylyl cyclase via a G protein of the Gi/Go family

Autoantibodies against the protein may result in pulmonary transfusion reactions

is found in the cytoplasm and crosslinked to membrane proteins by transglutaminase

and murine studies suggest a role in tumor-associated tissue remodeling

and has been shown to induce apoptosis and to activate NF-kappaB

VHL Polyclonal Antibody, 20ul[BT-AP09520] Vortex Mixer GALR1 inhibits adenylyl cyclase viaVon Hippel Lindau syndrome (VHL) is a dominantly inherited familial cancer syndrome predisposing to a variety of malignant and benign tumors. A germline mutation of VHL is the basis of familial inheritance of VHL syndrome. The protein encoded by VHL is a component of the protein complex that includes elongin B, elongin C, and cullin 2, and possesses ubiquitin ligase E3 activity. This protein is involved in the ubiquitination and degradation of hypoxia

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