GRK 2(Phospho Ser685) Polyclonal Antibody, 20ul Sampling Tubes is located on Chromosome 15

is located on Chromosome 15 and is an inhibitor of calcineurin activity and has a genetic phenotype associated with Parkinson's Disease (OMIM:606988)

calcium/calmodulin- dependent protein kinase II

and mutations in this gene have been associated with different neuromuscular diseases

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The encoded protein interacts with adrenocorticotropic and MSH hormones and is mediated by G proteins

GRK 2(Phospho Ser685) Polyclonal Antibody, 20ul Sampling Tubes is located on Chromosome 15The product of this gene phosphorylates the beta 2 adrenergic receptor and appears to mediate agonist specific desensitization observed at high agonist concentrations. This protein is an ubiquitous cytosolic enzyme that specifically phosphorylates the activated form of the beta adrenergic and related G protein coupled receptors. Abnormal coupling of beta adrenergic receptor to G protein is involved in the pathogenesis of the failing heart.