Rat C-Reactive Protein, CRP ELISA Kit, 96T Bottle-Top Dispenser Mutations in this gene may

Mutations in this gene may be associated with adult-onset sensorimotor neuropathy

Negatively regulates MAP3K5/ASK1 kinase activity

The encoded protein is synthesized mainly in corticotroph cells of the anterior pituitary where four cleavage sites are used

This protein is thought to play a regulatory role in keratinocyte proliferation and it may also be a regulator for rRNA transcription

Three transcript variants encoding different isoforms have been found for this gene

Rat C-Reactive Protein, CRP ELISA Kit, 96T Bottle-Top Dispenser Mutations in this gene mayDisplays several functions associated with host defense: it promotes agglutination, bacterial capsular swelling, phagocytosis and complement fixation through its calcium dependent binding to phosphorylcholine. Can interact with DNA and histones and may scavenge nuclear material released from damaged circulating cells (By similarity).