p53 Polyclonal Antibody, 50ul[BT-AP06815] Site-directed Mutagenesis The protein encoded by this

The protein encoded by this gene is a nuclear outer membrane protein that binds cytoplasmic F-actin

This protein is also a co-factor for transcriptional regulation by hypoxia-inducible factor 1

Mutations in this gene have been associated with Tangier's disease and familial high-density lipoprotein deficiency

The D-5 position also can be phosphorylated by type I PtdIns4P-5-kinases (PIP5Ks) that are encoded by distinct genes and preferentially phosphorylate D-4 phosphorylated PtdIns

This family member is thought to be play a role in reorganizing and regenerating the corneal matrix in granular and lattice type I dystrophies

p53 Polyclonal Antibody, 50ul[BT-AP06815] Site-directed Mutagenesis The protein encoded by thisTP53 encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The tumor protein p53 responds to diverse cellular stresses to regulate expression of target genes, thereby inducing cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism. Mutations in this gene are associated with a variety of human cancers, including hereditary cancers such as Li Fraumeni syndrome.