Human Serine Threonine-protein Phosphatase PP1-alpha Catalytic Subunit, PPP1CA ELISA Kit, 96T Site-directed Mutagenesis This gene encodes a protein

This gene encodes a protein that contains a WD-40 domain| and is thought to be involved in diphthamide biosynthesis

The toxin binds to the vesicular domain of Syt2 (residues 1-61) (PubMed: 15123599)

Downregulation of expression of this gene by promoter hypermethylation has been observed in a wide spectrum of human malignancies

May also be involved in pre-mRNA splicing

Mediates the proteasomal targeting of misfolded or accumulated proteins for degradation by binding (via UBA domain) to their polyubiquitin chains and by interacting (via ubiquitin-like domain) with the subunits of the proteasome (PubMed: 15147878)

Human Serine Threonine-protein Phosphatase PP1-alpha Catalytic Subunit, PPP1CA ELISA Kit, 96T Site-directed Mutagenesis This gene encodes a protein