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HECW1 Polyclonal Antibody, 20ul Serum This protein may be involved

SKU: 54323148028

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HECW1 Polyclonal Antibody, 20ul Serum This protein may be involvedE3 ubiquitin protein ligase that mediates ubiquitination and subsequent degradation of DVL1. Also targets the mutant SOD1 protein involved in familial amyotrophic lateral sclerosis (FALS). Forms cytotoxic aggregates with DVL1, SSR3 and mutant SOD1 that lead to motor neuron death in FALS.,pathway: Protein modification; protein ubiquitination.,Contains 1 C2 domain.,Contains 1 HECT (E6AP type E3 ubiquitin protein ligase) domain.,Contains 2 WW

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Description

This protein may be involved in completion and maintenance of the myelin sheath and in cell-cell communication

subcellular location:In (PubMed:11350957) diffuse granular localization in the cytoplasm surrounding the nucleus

suggesting that it may play a role in regulating genes in germ cells

LGALS3BP has been found elevated in the serum of patients with cancer and in those infected by the human immunodeficiency virus (HIV)

other organisms lack mariner transposase domain

HECW1 Polyclonal Antibody, 20ul Serum This protein may be involvedE3 ubiquitin protein ligase that mediates ubiquitination and subsequent degradation of DVL1. Also targets the mutant SOD1 protein involved in familial amyotrophic lateral sclerosis (FALS). Forms cytotoxic aggregates with DVL1, SSR3 and mutant SOD1 that lead to motor neuron death in FALS.,pathway: Protein modification; protein ubiquitination.,Contains 1 C2 domain.,Contains 1 HECT (E6AP type E3 ubiquitin protein ligase) domain.,Contains 2 WW

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