Smad7 (Acetyl Lys70) Rabbit Polyclonal Antibody, 100ul RNA Synthesis A pseudogene of ACKR4 is
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Smad7 (Acetyl Lys70) Rabbit Polyclonal Antibody, 100ul RNA Synthesis A pseudogene of ACKR4 isThe protein encoded by this gene is a nuclear protein that binds the E3 ubiquitin ligase SMURF2. Upon binding this complex translocates to the cytoplasm where it interacts with TGF beta receptor type 1 (TGFBR1) leading to the degradation of both the encoded protein and TGFBR1. Expression of this gene is induced by TGFBR1. Variations in this gene are a cause of susceptibility to colorectal cancer type 3 (CRCS3). Several transcript variants encoding
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