p21 (Acetyl Lys154) Rabbit Polyclonal Antibody, 100ul Culture Media sterilized by irradiation to SAL10^-6
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p21 (Acetyl Lys154) Rabbit Polyclonal Antibody, 100ul Culture Media sterilized by irradiation to SAL10^-6May be the important intermediate by which p53 mediates its role as an inhibitor of cellular proliferation in response to DNA damage. Binds to and inhibits cyclin dependent kinase activity preventing phosphorylation of critical cyclin dependent kinase substrates and blocking cell cycle progression. induction: By p53 mezerein (antileukemic compound) and interferon beta. PTM: Phosphorylation of Thr 145 by Akt or of Ser 146 by PKC impairs binding to
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