SMAD7 Polyclonal Antibody, 100ul Diagnostic Probes & Oligos Mutations in this gene have

Mutations in this gene have been associated with several diseases

The activity of eukaryotic elongation factor 2 kinase is increased in many cancers and may be a valid target for anti-cancer treatment

Mannose receptor C type 2 plays a role in extracellular matrix remodeling by mediating the internalization and lysosomal degradation of collagen ligands

CALD1 encodes a calmodulin- and actin-binding protein (caldesmon 1) that plays an essential role in the regulation of smooth muscle and nonmuscle contraction

Studies in other mammals suggest this protein plays a role in cell adhesion

SMAD7 Polyclonal Antibody, 100ul Diagnostic Probes & Oligos Mutations in this gene haveThe protein encoded by this gene is a nuclear protein that binds the E3 ubiquitin ligase SMURF2. Upon binding, this complex translocates to the cytoplasm, where it interacts with TGF beta receptor type 1 (TGFBR1), leading to the degradation of both the encoded protein and TGFBR1. Expression of this gene is induced by TGFBR1. Variations in this gene are a cause of susceptibility to colorectal cancer type 3 (CRCS3). Several transcript variants encoding