MSH2 Monoclonal Antibody, 100ul Sampling Tubes The coding sequence of this

The coding sequence of this gene contains a polymorphic region of 60 nt tandem imperfect repeat units

Upon binding the hormone ligand

consisting of several immunoglobulin-like domains and fibronectin-like repeats (type III)

In response to DNA damage and replication blocks| cell cycle progression is halted through the control of critical cell cycle regulators

The encoded protein may be required for normal galactose metabolism by maintaining the equilibrium of alpha and beta anomers of galactose

MSH2 Monoclonal Antibody, 100ul Sampling Tubes The coding sequence of thisThis locus is frequently mutated in hereditary nonpolyposis colon cancer (HNPCC). When cloned, it was discovered to be a human homolog of the E. coli mismatch repair gene mutS, consistent with the characteristic alterations in microsatellite sequences (RER+ phenotype) found in HNPCC. Two transcript variants encoding different isoforms have been found for this gene.