CARD 10 Polyclonal Antibody, 50ul Cell Dissociation Mutations in this gene result

Mutations in this gene result in heritable predisposition to colon and stomach cancer

Also CD63 has been associated with tumor progression

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Dok-5 protein undergoes tyrosine phosphorylation in response to insulin and insulin-like growth factor-1

Although the BCR-ABL fusion protein has been extensively studied

CARD 10 Polyclonal Antibody, 50ul Cell Dissociation Mutations in this gene resultThe caspase recruitment domain (CARD) is a protein module that consists of 6 or 7 antiparallel alpha helices. It participates in apoptosis signaling through highly specific protein protein homophilic interactions. Like several other CARD proteins, CARD10 belongs to the membrane associated guanylate kinase (MAGUK) family and activates NF kappa B (NFKB; see MIM 164011) through BCL10 (MIM 603517) (Wang et al., 2001 [PubMed 11259443]).