CABYR Polyclonal Antibody, 100ul sgRNA Library Construction WWOX (WW domain containing oxidoreductase)

WWOX (WW domain containing oxidoreductase) encodes a member of the short-chain dehydrogenases/reductases (SDR) protein family

Studies in mouse suggest that nuclear matrix transcription factors (NP/NMP4) may be part of a general mechanical pathway that couples cell construction and function during extracellular matrix remodeling

and its deficiency has been associated with the connective tissue disorder Ehlers-Danlos syndrome

In addition to being ubiquitinated by the VHL-E3 ligase complex| this enzyme deubiquitinates hypoxia-inducible factor (HIF)-1 alpha and thereby causes increased expression of HIF-1alpha targeted genes which play a role in angiogenesis| glucose metabolism| cell proliferation and metastasis

The protein associates with the p85 subunit of phosphatidylinositol 3-kinase and interacts with the fyn-binding protein

CABYR Polyclonal Antibody, 100ul sgRNA Library Construction WWOX (WW domain containing oxidoreductase)To reach fertilization competence, spermatozoa undergo a series of morphological and molecular maturational processes, termed capacitation, involving protein tyrosine phosphorylation and increased intracellular calcium. The protein encoded by this gene localizes to the principal piece of the sperm flagellum in association with the fibrous sheath and exhibits calcium binding when phosphorylated during capacitation. A pseudogene on chromosome 3 has been