PS-1 Polyclonal Antibody, 100ul Protein Post-translational Modification F8 produces two alternatively spliced

F8 produces two alternatively spliced transcripts

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MARCH2 reduces surface accumulation of several glycoproteins and appears to regulate early endosome-to-trans-Golgi network (TGN) trafficking

This gene belongs to the forkhead family of transcription factors which are characterized by a distinct forkhead domain

Heterodimerization leads to the activation of pathways which lead to cell proliferation or differentiation

PS-1 Polyclonal Antibody, 100ul Protein Post-translational Modification F8 produces two alternatively splicedAlzheimer's disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (PSEN1; PSEN2) or in the amyloid precursor protein (APP). These disease linked mutations result in increased production of the longer form of amyloid beta (main component of amyloid deposits found in AD brains). Presenilins are postulated to regulate APP processing through their effects on gamma secretase, an enzyme that cleaves APP.