SE6L2 Rabbit Polyclonal Antibody, 50ul Organelle Studies Mutations in APP have been

Mutations in APP have been implicated in autosomal dominant Alzheimer disease and cerebroarterial amyloidosis (cerebral amyloid angiopathy)

Proteins of this family are defined by a vacuolar protein sorting 10 domain at the N-terminus

This gene functions as a tumor suppressor

The encoded protein also anchors the actin cytoskeleton and may be responsible for transmitting the contact inhibition signal that causes cells to stop dividing once the epithelial sheet is complete

May play a direct role in a TNF-alpha signaling pathway leading to induction of cell death

SE6L2 Rabbit Polyclonal Antibody, 50ul Organelle Studies Mutations in APP have been