Presenilin 1(Phospho Ser357) Polyclonal Antibody, 50ul Plasmid Preparation The composition of the APC

The composition of the APC is highly conserved in organisms from yeast to humans

All GTPases of the Ras superfamily have in common the presence of six conserved motifs involved in GTP/GDP binding

PKC subfamily

This gene encodes a type I transmembrane protein and member of the immunoglobulin superfamily of cell adhesion molecules

Defects in PEX5 are a cause of neonatal adrenoleukodystrophy (NALD)

Presenilin 1(Phospho Ser357) Polyclonal Antibody, 50ul Plasmid Preparation The composition of the APCAlzheimer's disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (PSEN1; PSEN2) or in the amyloid precursor protein (APP). These disease linked mutations result in increased production of the longer form of amyloid beta (main component of amyloid deposits found in AD brains). Presenilins are postulated to regulate APP processing through their effects on gamma secretase, an enzyme that cleaves APP.