kobe2602 astin BX-795 displays higher growth inhibition
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kobe2602 astin BX-795 displays higher growth inhibitionKobe2602, is analog of Kobe0065 , is is a potent and selective RAS inhibitor, which exhibit inhibitory activity toward H Ras GTP c Raf 1 binding both in vivo and in vitro. Kobe2602 effectively inhibits both anchorage dependent and independent growth and induce apoptosis of H ras(G12V) transformed NIH 3T3 cells, which is accompanied by down regulation of downstream molecules such as MEK ERK, Akt, and RalA as well as an upstream molecule, Son of
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