MK-5108 Size:Solid 10 mg The histone deacetylase inhibitor MS-275

The histone deacetylase inhibitor MS-275 promotes differentiation or apoptosis in human leukemia cells through a process regulated by generation of reactive oxygen species and induction of p21CIP1/WAF1 1

PubMed PMID: 25420519

Schwartz GK

2016 Apr 19

Vincristine induces apoptosis in tumor cells and inhibits SH-SY5Y cell proliferation with IC50 of 0

MK-5108 Size:Solid 10 mg The histone deacetylase inhibitor MS-275MK 5108, also known as VX689, is a novel small molecule with potent inhibitory activity against Aurora A kinase. MK 5108 specifically inhibited Aurora A kinase in a panel of protein kinase assays. MK 5108 also induced phosphorylated Histone H3 in skin and xenograft tumor tissues in a nude rat xenograft model. MK 5108 inhibited growth of human tumor cell lines in culture and in different xenograft models. MK 5108 is currently tested in clinical trials