R-1479 Catalog No.:M10813-10 PIK-75 Hydrochloride

PIK-75 Hydrochloride

Formula: C15H9N5O

the JAK2V617F gain-of-function mutation involves a valine-to-phenylalanine modification at position 617

29)26-14-4-3-5-21(26)22(27)25-23-24-20(15-31-23)17-8-10-18(30-2)11-9-17/h6-13

Crossing the blood brain barrier

R-1479 Catalog No.:M10813-10 PIK-75 HydrochlorideR 1479, also known as 4' azidocytidine, is a potent inhibitor of NS5B dependent RNA synthesis and hepatitis C virus replication in cell culture. R 1479 is a specific inhibitor of HCV replication in the HCV subgenomic replicon system (IC(50) = 1. 28 microM). The corresponding 5' triphosphate derivative (R1479 TP) is a potent inhibitor of native HCV replicase isolated from replicon cells and of recombinant HCV polymerase (NS5B) mediated RNA synthesis