SB 271046 Hydrochloride - CAS# 209481-24-3 azine Hydrochloride Smiles: CC(C)C1C(=O)N2N=CC(C#N)=C2NC=1C1C=CC=CC=1
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SB 271046 Hydrochloride - CAS# 209481-24-3 azine Hydrochloride Smiles: CC(C)C1C(=O)N2N=CC(C#N)=C2NC=1C1C=CC=CC=1SB 271046 is one of the first selective 5 HT6 receptor antagonists to be discovered. SB 271046 was found to be potent and selective in vitro and had good oral bioavailability in vivo, but had poor penetration across the bloodbrain barrier. SB 271046 was found to increase levels of the excitatory amino acid neurotransmitters glutamate and aspartate, as well as dopamine and noradrenaline in the frontal cortex and hippocampus of rats, and 5 HT6
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