CCT241533 - CAS# 1262849-73-9 cetate Hydrochloride) 28(3):257-65

28(3):257-65

NU7026 (10 μM) potentiates ionizing radiation (IR) cytotoxicity [potentiation factor at 90% cell kill (PF90)=1

29)30/h3-15H

4-dichlorophenoxy)methyl]-2-fluoro-N-methanesulfonylbenzamide

Formula: C18H14Cl2F2N4O2

CCT241533 - CAS# 1262849-73-9 cetate Hydrochloride) 28(3):257-65CCT 241533 dihydrochloride is a potent Chk2 inhibitor (IC50 = 3 nM). It shows >63 fold selectivity for Chk1 over Chk2 and a panel of 84 other kinases. CCT 241533 dihydrochloride inhibits Chk2 activation in response to etoposide induced DNA damage in HT29 cells and blocks ionizing radiation induced apoptosis of mouse thymocytes. Product information CAS Number: 1262849 73 9 Molecular Weight: 442. 48 Formula: C23H27FN4O4 Synonym: CCT 241533 CCT 241533