Genz-123346 - CAS# 943344-58-9 Catalog No.:M8318-2 1329:93-106

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Genz-123346 - CAS# 943344-58-9 Catalog No.:M8318-2 1329:93-106Genz 123346 is a potent and selective glucosylceramide synthase inhibitor with potential anticancer activity. Exposure of cells to Genz 123346 and to other GCS inhibitors at non toxic concentrations can enhance the killing of tumor cells by cytotoxic anti cancer agents. Genz 123346 and a few other GCS inhibitors are substrates for multi drug resistance efflux pumps such as P gp (ABCB1, gP 170). In cell lines selected to over express P gp or which

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