Furamidine dihydrochloride - PRMT1 Inhibitor. CAS# 55368-40-6 0183 selective and cell permeable inhibitor

selective and cell permeable inhibitor of DNA methyltransferase

Acalabrutinib inhibits purified BTK with an IC50 of 3 nM and an EC50 of 8 nM in a human whole-blood CD69 B cell activation assay

Giuliano S

1421227-52-2

Chemical Name: 5-(3-chlorophenyl)-N-(4-(morpholinomethyl)phenyl)furan-2-carboxamide

Furamidine dihydrochloride - PRMT1 Inhibitor. CAS# 55368-40-6 0183 selective and cell permeable inhibitorFuramidine, CAS No. 55368 40 6, is a potent, selective and cell permeable Protein arginine methyltransferase 1 (PRMT1) inhibitor with IC50 of 9. 4 M. It has >10 fold selectivity PRMT5, PRMT6 and CARM1 (IC50 are 166, 283 and >400 M respectively). It targets the enzyme active site and is primarily competitive with the substrate and noncompetitive toward the cofactor. Furamidine effectively inhibits intracellular PRMT1 activity and blocks cell