VX-222 cis - CAS# 1026785-59-0 Catalog No.:M10875-2 Biomol Ther (Seoul)

Biomol Ther (Seoul)

InChiKey: PZEAMYHHAKUANN-UHFFFAOYSA-N

serving many of the same functions that cholesterol serves in animal cells

also known as ST1926

LY294002 was used at 10-50 µM final concentration in various in vitro assays

VX-222 cis - CAS# 1026785-59-0 Catalog No.:M10875-2 Biomol Ther (Seoul)Lomibuvir, also known as VX 222, VCH 222 and VX22, is an nonnucleoside NS5B polymerase inhibitor. VX 222 inhibits the 1b Con1 HCV subgenomic replicon, with 50% effective concentrations (EC(50)s) 5 nM. VX 222 binds to the HCV polymerase with dissociation constants of 17 nM. In phase 1 and 2 clinical studies, VX 222 demonstrated effective antiviral efficacy, with substantial reductions in plasma HCV RNA in patients chronically infected with genotype 1