BAY 87-2243 - Hypoxia-inducible Factor-1 (HIF-1) Inhibitor. CAS# 1227158-85-1 0165 InChi: InChI=1S/C23H21N5O3S

InChi: InChI=1S/C23H21N5O3S

Bornmann W

and promote naïve state of pluripotent stem cells

Laughlin JD

MDL29951 promotes Ca2+ signaling responses and inhibition of cyclic adenosine monophosphate (cAMP) accumulation in rat oligodendrocyte precursor cells during the period of peak GPR17 abundance

BAY 87-2243 - Hypoxia-inducible Factor-1 (HIF-1) Inhibitor. CAS# 1227158-85-1 0165 InChi: InChI=1S/C23H21N5O3SBAY 87 2243, CAS No. 1227158 85 1, is a highly potent and selective inhibitor of hypoxia induced gene activation, which has antitumor activities by inhibition of mitochondrial complex I. BAY 87 2243 mproves local tumor control after fractionated irradiation in a schedule dependent manner in head and neck human xenografts. BAY 87 2243 markedly decreased nuclear HIF 1 expression and pimonidazole hypoxic fraction already after 3 days of drug treatment.