RI-1 - CAS# 415713-60-9 ihydrochloride it inhibits the tyrosine kinase

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RI-1 - CAS# 415713-60-9 ihydrochloride it inhibits the tyrosine kinaseRI 1 is an irreversible inhibitor of RAD51 (IC50s = 5 30 M), a protein that is central to homologous recombination during DNA repair and is overexpressed in a wide range of human cancer cell types. RI 1 specifically reduces gene conversion in human cells while stimulating single strand annealing. RI 1 binds covalently to the surface of RAD51 protein at cysteine 319 that likely destabilizes an interface used by RAD51 monomers to oligomerize into

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