BML-277 ubasumstat (TAK-981) InChi: InChI=1S/C35H60N2O4
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BML-277 ubasumstat (TAK-981) InChi: InChI=1S/C35H60N2O4BML 277, also known as Chk2 Inhibitor II, is a Chk2 (checkpoint kinase 2) inhibitor. BML 277 protects T cells from apoptosis by controlling the response of p53 to radiation induced DNA breaks. ML 277 has IC50 = 15 nM; Ki = 37 nM. ML 277 shows 1000 fold greater selectivity for the Chk2 serine threonine kinase than for the Cdk1 B and CK1 kinases (for which IC50 = 12 M and 17 M, respectively). Product information CAS Number: 516480 79 8 Molecular Weight:
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