Metolazone Catalog No.:M9303-10 is a selective non-lipid inhibitor

is a selective non-lipid inhibitor of sphingosine kinase (IC50 = 0

and 100 nM (10 μL)

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Roflumilast N-oxide at 2 nM partly mitigates the cigarette smoke extract (CSE)-induced epithelial to mesenchymal transition (EMT) in WD-HBEC in vitro

Metolazone Catalog No.:M9303-10 is a selective non-lipid inhibitorMetolazone is a thiazide like diuretic. It is primarily used to treat congestive heart failure and high blood pressure. Metolazone indirectly decreases the amount of water reabsorbed into the bloodstream by the kidney, so that blood volume decreases and urine volume increases. This lowers blood pressure and prevents excess fluid accumulation in heart failure. Metolazone is sometimes used together with loop diuretics such as furosemide or bumetanide,